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KMID : 0978920180190010049
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Korean Journal of Clinical Geriatrics
2018 Volume.19 No. 1 p.49 ~ p.54
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Association between Serum Carcinoembryonic Antigen Levels within Normal Range and Metabolic Syndrome in Korean Women Aged ≥50 Years Old
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Park Hye-Min
Kwon Yu-Jin
Park Hea-Yoon
Lee Yong-Jae
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Abstract
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Background: The objective of this study was to investigate the relationship between serum carcinoembryonic antigen (CEA) levels and metabolic syndrome in Korean women aged ≥50 years old.
Methods: This cross-sectional study included a total of 3,479 individuals who underwent health check-ups between November 2006 and July 2010 at the Health Promotion Center of Gangnam Severance Hospital in Seoul. Serum CEA levels were categorized into quartiles: Q1 (≤1.0 μg/L), Q2 (1.1~1.4 μg/L), Q3 (1.5~2.1 μg/L), and Q4 (≥2.2 μg/L). The odds ratio (OR) and 95% confidence interval (CI) for metabolic syndrome were calculated using multiple logistic regression analysis after adjusting for confounding factors across CEA quartiles.
Results: The mean CEA levels were increased in people with obesity, high blood pressure, and high plasma glucose. Compared with the lowest CEA quartile, the OR (95% CI) for metabolic syndrome in the highest CEA quartile was 1.34 (1.03 to 1.73) after adjusting for age, cigarette smoking, alcohol intake, regular exercise, and leukocyte count.
Conclusion: CEA was significantly related with metabolic syndrome in middle aged and elderly Korean females, and elevated CEA levels may be a surrogate marker for metabolic syndrome.
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KEYWORD
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Carcinoembryonic antigen, Metabolic syndrome, Inflammation, Elderly
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